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Oxcarbazepine, structurally related to carbamazepine, appears to be as effective as carbamazepine in the treatment of epilepsy and slightly better tolerated.
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The gamma-amino butyric acid (GABA) hypothesis suggests that the GABA-receptor complex (GABA-binding site, chloride channel, and barbiturate and benzodiazepine receptor sites) is an important neuronal inhibitor, and that GABA-ergic transmission interacts with ammonia in the pathogenesis of HE.
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Allergic reaction to radiographic dye, including nausea and vomiting, may interrupt the procedure.
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According to yet another aspect, the present invention provides a method for treating a disease or disorder comprising administering to a patient in need thereof a pharmaceutical composition comprising as an active ingredient a flumazenil complex, and at least one pharmaceutical acceptable carrier, wherein the disease or disorder is selected from the group consisting of: excessive sleepiness, alcohol intoxication and hepatic encephalopathy.
Dosing of the sublingual flumazenil lozenges began at one 6-mg lozenge four times daily, titrating up by adding an extra lozenge every 4-5 days until reaching a maximum of 12 per day.
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In two other instances, the relationship to taper is indeterminate; in both of these cases the patients had been receiving doses of 3 mg daily prior to seizure.
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Body as a Whole: rigors, shivering Cardiovascular System: arrhythmia (atrial, nodal, ventricular extrasystoles), bradycardia, tachycardia, hypertension, chest pain Digestive System: hiccup Nervous System: speech disorder (dysphonia, thick tongue) Not included in this list is operative site pain that occurred with the same frequency in patients receiving placebo as in patients receiving flumazenil for reversal of sedation following a surgical procedure.
Generally considered one of the safest sedative agents, chloral hydrate does have the potential for causing unexpectedly deep levels of sedation as well as upper airway obstruction in some patients.
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The other oral sedatives such as the benzodiazepines can also be readily used.
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Long-term use of diazepam for the management of epilepsy is not recommended; however, a subgroup individuals with treatment resistant epilepsy benefit from long-term benzodiazepines and for such individuals clorazepate has been recommended due to its slower onset of tolerance to the anticonvulsant effects.
However, this method of treatment is not right for every person.
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Use of flumazenil in this age group is supported by evidnece from adequate and well-controlled studies of flumazenil in adults with additional date from uncrontrolled pediatric studies including one open-label trial.
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Murray gave him lesser amounts (lower doses and lower drip rate) and gave lorazepam and midazolam as well.
The benzodiazepines that were initially FDA-approved for insomnia, such as (Restoril) or (Halcion), are not used as frequently today due to the availability of the newer nonbenzodiazepine drugs, such as (), (), or ().
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Reversal: Flumazenil (Romazicon) will reverse the respiratory effects of midazolam overdose.
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The safety and efficacy of flumazenil have not been established in pediatric patients for reversal of the sedative effects of benzodiazepines used for induction of general anesthesia, for the management of overdose, or for the resuscitation of the newborn, as no well-controlled clinical studies have been performed to determine the risks, benefits and dosages to be used.
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Flumazenil acts as an antidote for pharmacological and toxic effects due to benzodiazepines.
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